Tristin Alexander Schwartze
Trystyn.Alxander@gmail.com
MBSB at University of Pittsburgh; Pittsburgh, PA
TAS224@pitt.edu

Future Goals: My long-term interests are in methods development aimed at protein-design, gene-editing, and viral-delivery. In the short-term, I'm interested in learning. Understanding diverse methods, mechanisms, and analyses will be extremely relevant to my development as a scientist. With the intention of high competence, I'm familiarizing myself with with every aspect of my work. From theoretical to applications and from computational to experimental, I'm learning as much as I can. For the time being, learning is my goal.

Recent Research

While I now work in structural biophysics, I worked on sensors and drug-delivery-systems in my undergraduate work and briefly dabbled with computational biophysics in my graduate rotations. I'm currently working as a Graduate Research Assistant with Professor Hinck, an expert on the TGF-β Super Family.
Previous Work Experience

Graduate Research Assistant at the University of Pittsburgh.

MDM2's Val93 in docking p53's Trp23: Docked p53's Trp23 into MDM2. Monitored dihedral angle of Val93. Project Incomplete.

Experience & Training:
  • Limited Experience with NAMD.
  • Limited Experience with Steered MD.
     (Third Rotation)

Pocket Conformation Progress Coordinate for WestPA: The goal of this rotation was to establish a progress coordinate representative of pocket conformation (size and shape) to allow for efficient sampling using the Weighted Ensemble path sampling algorithm via WestPA and NAMD Molecular Dynamics. Project Incomplete.

Experience & Training:
  • Limited Experience with NAMD.
  • Limited Experience with WESTPA.
    (Second Rotation)

Using WestPA to Characterize Foldon Monomer Folding: Characterize the Foldon Trimerization Domain's folding and unfolding processes using the Weighted Ensemble path sampling algorithm via WestPA and AMBER Molecular Dynamics. Project Incomplete.

Experience & Training:
  • Limited Experience with AMBER.
  • Limited Experience with WESTPA.
     (First Rotation)
Research Assistant for the Melendez Lab.

Collagen-Encapsulation Drug Delivery System: The creation and optimization of collagen nano-particles to encapsulate drugs of interest. Characterized functionality as a drug delivery system (size, dispersity, spontaneous release, storage, toxicity, etc.)

Experience & Training:
  • Tabletop and LEO SEMs.
  • Common Protocol & Machines:
    • Cell Culture (Mammalian)
    • Gel-based Assays (e.g. SDS-PAGE)
    • Plate-Readers & Assays
    • Autoclave
    (Summer 2016)

High-Throughput SPR Sensors for Matrix Metalloproteinases: Surface Plasmon Resonance sensors coated in collagen to detect collagenase degradation. Attempted to make quantitative measurements of collagenase concentrations via kinetic association constants and an SPR degradation formulas.

Experience & Training:
  • Surface Plasmon Resonance (SPR).
  • Nanoenabler, ArrayIt, & Soft Lithography.
  • Microfluidics.
    (Summer 2015)
Education

2017‑????Graduate Student at the University of Pittsburgh's Molecular Biophysics and Structural Biology Graduate Program.
2015‑2017B.S. in NanoScience
College of Nanoscale Science and Engineering (CNSE), Albany NY
2012‑2014A.S. in Science and Mathematics
Northwest Missouri State University, Maryville MO
Meetings and Publications

Honors and Scholarships

Relevant Courses Taken

Biology & Proteins Math & Programing Physics
Molecular Biophysics II Thermo. & Stat. Mechanics Advanced Phys/Chem Concepts
Molecular Biophysics I Analysis for Applications Charged Particle Optics
Foundations of Biomedical Science Linear Algebra Nanoscale Electronic Devices
Organic Chemistry I Multi-Variable Calculus Nanoscale Design
Nano. Chem. and Bio. Sensors Scientific Computing NanoLab I & II
Soft Matter Programing I & II Structure of Matter
Nanobio. for Nanotech. Apps. Advanced Circuits
Nanobiomanufacturing Quantum Origins of Mat. Prop.
Biochemistry Intro. to Quantum Theory
Microbiology
Hobbies & Interests

  • Philosophy of Science
  • Misc. Coding & Web Design